Dr. Alexander Craig Mackinnon, Jr

Patologia Molecular Estados Unidos

POSITION TITLE: Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

University of Colorado, Boulder, CO BA 12/1991 Molecular Biology
Northwestern University, Evanston, IL MS 12/1994 Neurobiology/Physiology
University of Illinois, Urbana, IL MD 05/2004 Medicine
University of Illinois, Urbana, IL PhD 05/2004 Cell and Structural Biology
University of Chicago Medical Center, Chicago, IL Residency 06/2007 Anatomical Pathology
University of Chicago Medical Center, Chicago, IL Fellowship 06/2008 Cardiovascular Pathology
University of Chicago Medical Center, Chicago, IL Fellowship 06/2010 Molecular Genetic Pathology

A. Personal Statement
I serve as the Director of the Division of Genomics, Diagnostics, and Bioinformatics in the Department of Pathology at the University of Alabama at Birmingham. As a dual board-certified anatomical and molecular pathologist, I provide guidance related to the pathology, histology, immunohistochemistry, molecular cytogenetics (e.g., FISH and microarray) and molecular pathology (e.g., massively parallel sequencing) of human tissue samples. During my career, I have successfully collaborated with others to identify biomarkers that support the diagnosis and therapy for cancers. I possess the technical experience, academic training, and management skills to ensure that experiments are well designed, properly executed and appropriately analyzed. In my current roles, I review the histology of hundreds of human cancer specimens. Therefore, I am well suited to perform the histopathological and molecular assessment of these cancers. In short, I am well suited to serve as Director of the Division of Genomics, Diagnostics, and Bioinformatics, and I am committed to further advancing these goals and technologies.

B. Positions and Honors
Positions and Employment
2004–2010 House staff,University of Chicago Medical Center,Chicago, IL
2004–2007 Resident, Anatomical Pathology, University of Chicago Medical Center,Chicago, IL
2007–2008 Postdoctoral Fellow, Cardiovascular Pathology, University of Chicago Medical Center, Chicago, IL
2008–2009 Clinical Fellow, Molecular Genetics, University of Chicago Medical Center, Chicago, IL
2009–2010 Clinical Fellow, Molecular Genetic Pathology, University of Chicago Medical Center,Chicago,IL
2010–2018 Director, Medical College of Wisconsin, Pathology, Milwaukee, WI
2010–2019 Attending Physician,Froedtert Memorial Lutheran Hospital, Pathology, Milwaukee, WI
2010–2015 Assistant Professor, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
2015–2019 Associate Professor, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
2017-2019

2019-Present
2019-Present Medical Director, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI
Professor, Department of Pathology, University of Alabama at Birmingham
Director of the Division of Genomics, Diagnostics, and Bioinformatics in the Department of Pathology at the University of Alabama at Birmingham

Other Experience and Professional Memberships
2006– Association for Molecular Pathology, AMP
2007– College of American Pathologists, CAP
Honors
1995 Star Tech Award, Abbott Laboratories
1998 Chairman, 10th Annual Medical Scholars Program Spring Research Symposium
1998 Instructors Ranked in Top 10% for Excellence in Teaching University of Illinois
1999 First Place, Outstanding Student Poster Presentation, 39th Annual Midwest Development Biology Meeting
1999–2001 Predoctoral Fellowship, American Heart Association
2000 First Place, Outstanding Oral Presentation, 40th Annual Midwest Development Biology Meeting
2001 Summer Research Fellowship, University of Illinois College of Medicine
2002–2004 Medical Scholars Program Class Representative, Elected Position
2006 Travel Award, American Society of Nephrology Annual Meeting
2007–2009 Cardiovascular Sciences Training Grant, Dr. Elizabeth McNally, PI
2008 Bursary Award, XXVII Congress of the International Academy of Pathology
2009 Trainee Travel Award, The Intersociety Council for Pathology Information
2009 Young Investigator Award, Association for Molecular Pathology
2011
Interdisciplinary Cancer Research Postdoctoral Fellowship Award, “The Prognostic Significance of SmgGDS-mediated Signaling Pathways in Breast Cancer”
2015 Technologist Award, Association for Molecular Pathology, “Myxoinflammatory Fibroblastic Sarcoma: Association of t(1;10) Translocations in a Cohort of 49 Cases by Fluorescence in Situ Hybridization” (Presented by Stephanie Puetz (Springborn))
2016 Archer Research Challenge Grants
2017 Technologist Award, Association for Molecular Pathology, “Validation of a Clinical Targeted CNS Next Generation Sequencing Panel for Detection of SNPs, Indels and 1p/19q Co-deletion” (Presented by Stefano Rosati)

C. Contributions to Science

1. Immunohistochemical Analysis of Melanoma and Skin Cancer. Utilization of immunohistochemistry to characterize human tissue in normal and pathological conditions.
a. Plaza JA, Bonneau P, Prieto V, Sangueza M, Mackinnon A, Suster D, Bacchi C, Estrozi B, Kazakov D, Kacerovska D, Falconieri G, Suster S. 2016. Desmoplastic melanoma: an updated immunohistochemical analysis of 40 cases with a proposal for an additional panel of stains for diagnosis. Journal Cutaneous Pathology. Apr;43(4):313-23. PubMed PMID: 26661921.
b. Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S. 2015. Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study. American Journal of Dermatopathology.5 Nov;37(11):809-21. PubMed PMID: 26485238.
c. Harding-Jackson N, Sangueza M, Mackinnon A, Suster S, Plaza JA. Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX. American Journal Dermatopathology. 2015 Jul;37(7):509-14; PubMed PMID: 26098709.
2. Morphological and Genetic Analysis of Human Tissues. Comparison of genetically normal, genetically abnormal, and drug-treated murine and human tissues
a. Lyros O, Nie L, Moore T, Medda R, Otterson M, Behmaram B, Mackinnon A, Gockel I, Shaker R, Rafiee P. Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett’s-associated Esophageal Adenocarcinoma. Mol Cancer Res. 2016 Apr 15. PubMed PMID: 27084312.
b. Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Otterson MF, Behmaram B, Gockel I, Mackinnon A, Shaker R. Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett’s Esophagus: Regulation via Dickkopf-1. Neoplasia. 2015 Jul;17(7):598-611PubMed PMID: 26297437; PubMed Central PMCID: PMC4547437
c. Samuels TL, Yan J, Khampang P, Mackinnon A, Hong W, Johnston N, Kerschner JE. (2016). Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media. International Journal of Pediatric Otorhinolaryngol. 88:104-8. PubMed PMC4978186
d. Samuels T.L., Yan J.C., Khampang P., Dettmar P.W., Mackinnon A., Hong W., Johnston N., Papsin B.C., Chun R.H., McCormick M.E., Kerschner J.E. 2017. Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion. JAMA Otolaryngology Head Neck Surg. 2017 Jun 8. PubMed PMID: 28594978.

Complete List of Published Work:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1t7oWIZidYQW/bibliography/48072103/public/?sort=date&direction=ascending

D. Additional Information: Research Support and/or Scholastic Performance
Completed Research Support
R01 CA157881 Wang (PI) 07/01/12–07/01/14
Genetic Determinants of Gene Expression Phenotype
Description: Perform NGS on circulating, cell free DNA to determine CNV in patients with prostate cancer. We identified a signature that correlated with the stage of disease in these men.
Role: Co-Investigator

Advancing a Healthier Wisconsin Traktman (PI) 07/01/13–12/01/14
The Role of the Protein Kinase VRK1 in Human Breast Cancer
Description: Performed quantitative immunohistochemistry of human breast cancer to quantify expression of the oncogene VRK1.
Role: Co-investigator

Localização

Bourbon Resort
Cataratas do Iguaçu

Av. das Cataratas, 2345 - Vila Yolanda, Foz de Iguazu - Paraná

Gerenciamento

Gerenciamento

Contatos

contato@ccmew.com

Avenida Paulista 352 Cj. 25 – Bela Vista – São Paulo


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